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Baseline gut microbiota is considered a primary factor influencing individual responses to dietary interventions ( 6.4 Novel perspectives in pharmacotherapy 6.4.1 Effects of conventional medications on microbiota Antidepressant medications have antimicrobial properties that can directly affect gut microbiota ( Akkermansia muciniphila and Escherichia coli , respectively ( Faecalibacterium and Parasutterella in antidepressant-treated patients with MDD were consistently depleted, along with Bifidobacterium enrichment ( 6.4.2 Novel microbiota-targeted therapeutics The development of novel therapeutics based on gut microbial mechanisms is emerging

Following expression and purification, the N-terminal extension is removed, exposing Lys26