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Although the study primarily reports clinical outcomes, changes in specific biomarkers indirectly suggest potential mechanisms of action of GLP-1RAs

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A higher metabolic rate translates into increased flexibility in how the body metabolizes fats and carbs, which can assist type 2 diabetics and obese individuals in managing long-term health

Cardiac arrhythmias Trials also reported a small number of cases of cardiac arrhythmias, including supraventricular arrhythmias and prolonged QT syndrome

Strokes are one of the main causes of adult disability

This asymmetry means that while retatrutide's Phase 2 numbers are numerically impressive, they carry substantially more uncertainty than semaglutide's Phase 3 results