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Aggregated -synuclein fibrils, dopamine-derived quinones, and mitochondrial DAMPs, including cardiolipin and mtDNA, are strong inducers of microglial NLRP3 inflammasome activation in PD

The goal is not to suppress immunity broadly

Angiopep-2, the ligand of the low-density lipoprotein receptor-related protein enhanced the BBB transcytosis of star-shaped, multibranched poly(l-glutamic acid) nanoconjugates in animals [50]

Since GPX4 has these characteristics, it plays a crucial role in inhibiting ferroptosis, which has received widespread attention

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It's like having a personal bodyguard for each of your 37 trillion cells