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PMID: 31883664 Biehl W, et al

Super responders must prioritize high protein intake and resistance training to protect their metabolism. Nutrient Deficiencies: If the "fullness" signal is too strong, patients may struggle to eat enough calories to sustain basic organ function

Improper needle depth, inconsistent site selection, and poor reconstitution practices all introduce variables that the clinical trials controlled for

On a GLP-1, the direction worth watching is a steep drop, which usually points back to not eating enough protein

However, the simultaneous GLP-1 and GIP agonism appears to counterbalance this effect while still allowing glucagon to drive its metabolic benefits