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A GP or specialist can assess whether an individual's medical history, current medications, or underlying conditions make the use of a GLP-1/GIP/glucagon receptor agonist particularly risky

They can also personalize their recommendations to fit your personal preferences, routine, and food budget

It seems to strike a "Goldilocks" balance where the metabolic burn is high, but the heart rate elevation (a common side effect of Glucagon activation) remains manageable for many subjects

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In addition to their neuroprotective role, GLP-1 analogs have also been studied for their influence on spinal excitatory synaptic transmission under pathophysiological conditions such as neuropathic pain

Theres no requirement or strong rationale to try Saxenda first