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For instance, in the head-to-head SURMOUNT-5 trial, the rate of discontinuation due to AEs was numerically lower for Tirzepatide (6.1%) compared to semaglutide 2.4 mg (8.0%), although the study was not powered for a formal statistical comparison of safety outcomes

Of these factors, estrogen is particularly critical since fibroids are considered estrogen dependent because no prepubertal cases have been described in the literature, and tumors tend to regress after menopause

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This result has been documented in porcine models: AUC GH is 2 to 4 times higher compared to each compound as monotherapy

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