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During phase 3 trials, it was administered as a once-weekly injection just under the skin, most often in the abdomen, thigh, or upper arm

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10.1089/ars.2007.1957 45 Van HemelrijckM.JungnerI.WalldiusG.GarmoH.BindaE.HaydayA.et al (2011)

Zeitschrift fr Mikroskopisch-Anatomische Forschung

Thus, an increase in NRF2 activity, reflected by induction of NRF2 target genes, likely represent an important mechanism mediating the protection seen in GCLM KO mice

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