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On the critical side: nausea in weeks 14 is the most common reason for early discontinuation, and some patients report that the weight loss plateau arrives around month 45 even on the full dose
JAMA Intern Med 2022;182:513-9.ArticlePubMedPMC 40
Initially, the body compensates for this by enhancing insulin secretion leading to abnormally high concentrations of insulin in the blood, a condition called hyperinsulinemia
Figure 7: Photograph of Leonard Thompson in 1930 together with (A) his medical record and (B) chart of his blood sugar levels from December 1921 to January 1922 (credit:Thomas Fisher Rare Book Library, University of Toronto)
For most patients, weekly dosing with semaglutide is easier
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