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In vitro , GSH-deficient hepatocytes show upregulated mRNA levels of DNA methyltransferase, Tet2, and Tet3, along with increased Dnmt activity (5-mC) and global DNA methylation levels

GPX4 converts reduced glutathione (GSH) to oxidized glutathione (GSSG) and reduces toxic lipid peroxides (R-OOH) to corresponding alcohols (R-OH) or free hydrogen peroxide (H 2 O 2 ) to water (Ingold et al., 2018

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Secondly, the role of these targets in the progression of chronic liver disease to HCC may be variable, and the underlying mechanisms are unknown

Tsai J-C, Perrella MA, Yoshizumi M, Hsieh C-M, Haber E, Schlegel R, and Lee M-E (1994)

Is this review biased because Pickart discovered GHK-Cu