At baseline and weeks 10 and 20, participants underwent brain magnetic resonance imaging and spectroscopy protocols and cognitive testing and provided blood samples after fasting
Researchers further enhanced the GLP-1 signaling pathway using the GLP-1 receptor agonists Exendin-4 (Exenatide) or Tirzepatide
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(2020) 5(9):e132747
Over time, the body can downregulate its response to consistent receptor stimulation