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Diabetes Ther (2021) 12:14357
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Furthermore, pre-existing DR and insulin use were identified in individuals at high risk of developing DR, and no increased risk of DR with semaglutide OW versus placebo was observed in those without pre-existing DR, regardless of whether insulin treatment was used [58]
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The PIONEER PLUS trial demonstrated that higher doses of oral semaglutide (25mg and 50mg) achieved HbA1c reductions of 1.9-2.2 percentage points when added to existing oral diabetes medications
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