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Both drugs are intended for use as adjuncts alongside caloric restriction and increased physical activity for weight management in obese or overweight adults and children aged 12 to 17 years with at least one weight-related comorbidity, such as T2D, dyslipidemia or hypertension, 15, 21

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This dual improvement in glucose and lipid homeostasis suggests potential applications in research focusing on insulin sensitivity and fatty liver prevention

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization

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