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Yale Medicine physicians recommend the following: Confirm the indication: GLP-1 medications are approved for specific body mass index (BMI) thresholds and medical conditions

There was some evidence of publication bias (Egger test, P = 0.94), but the trim-and-fill method indicated that this publication bias did not impact the estimate

While most are approved for the management of type 2 diabetes, some formulations, such as semaglutide (Wegovy) and tirzepatide (Zepbound), have also been approved for chronic weight management in adults with obesity or overweight

GLP-1 medications have been used to treat diabetes for the last twenty plus years

The unique generation and function of active GLP-1 has influenced growing interest in the hormone, and its reputation as an important biomarker in type 2 diabetes research 16,21,23

They admit that can be controversial, but they write that obesity may have phenotypic characteristics that resemble addiction, including neurocircuitry mechanisms