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The implications for conditions involving compromised blood flow are significant, though human confirmation of this mechanism remains needed

GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas

If a higher dose is required, they might use the gluteal muscle

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Primary outcomes were all-cause and CV mortality