Longitudinal melanonychia associated with inflammatory nail disorders: Multiple longitudinal melanonychia may occur in patients with lichen planus, which is typically associated with nail plate thinning, onychoatrophy, onychorrhexis, longitudinal splitting, longitudinal grooves or ridges of the nail plate, nail scarring, and abnormalities[19]
This is to reduce the chance of infection
Svoboda J, Stankova A, Entlerova M, Stuchlik A
Terry Restivo is a gem
J Pharmacol Exp Ther 363:92103
The concept works like this: by presenting the body's own peptide epitopes, the fragments of self-proteins that T cells recognize, in a tolerogenic context, researchers can selectively delete or suppress the specific T cell clones responsible for autoimmune attack