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Unlike caloric restriction, which triggers adaptive metabolic reprogramming, including enhanced autophagy and neuronal plasticity 69,70 , semaglutide primarily reduces food intake through appetite suppression 71

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patients should report unusual or severe symptoms promptly

Zeng Z, Luo Y, Xu X, Shan T, Chen M, Huang Z, et al

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In fact, over the past couple of decades, aberrant intracellular ROS levels and the cell's inability to clear the oxidants have been implicated in various diseases, including cancer, neurodegenerative disease, cardiovascular disease, diabetes, and gastrointestinal disease (Box 2)