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Destabilization of the glycosyl bond between the nitrogenous base and ribose sugar creates apurinic sites as the unstable adducts are lost from DNA

Any change runs through formal rulemaking that could take many months

This is the most common cause of nodules

Best Starting Points: Walking Slow weight training with full recovery between sets Avoid: CrossFit, OrangeTheory, and HIIT (until stabilized) If you feel worse after workouts (fatigue, naps, illness), scale back immediately

Most patients describe it as feeling like a small pinch that lasts maybe three seconds