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Grids of both WT and E1435Q Ycf1 in apo conditions were prepared as described in the methods, but only the E1435Q Ycf1 dataset yielded homogenous particles from which we successfully identified not one but two inward-facing conformations determined to 3.4 and 4.0 resolution (Fig

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Recently, evidence has emerged demonstrating benefits of GLP-1 receptor agonists in other medical conditions e.g

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Table 2 Original human studies on the physiological determinants of perinatal glucocorticoid sensitivity