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In addition, to assess whether the lipid biomarker candidates identified in the discovery cohort were specific for RA, anonymized serum samples from patients with systemic lupus erythematosus (SLE) were included in the validation cohort ( Figure 1 )

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Finally, some drugs or natural compounds have been reported to have antitumor properties by targeting metabolic vulnerabilities such as alterations in glycolysis, OXPHOS, and glutamine metabolism [13]

b Four time-points: T1, T2, T3, T4

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A comprehensive set of laboratory tests was conducted as part of the analysis, including eGFR, proteinuria, white blood cell, platelet, total cholesterol, glycohemoglobin (HbA1C), aspartate aminotransferase, and sodium