glp 1 long term studies Is Long-Term GLP-1 Use Safe? GLP-1 for Prevention: Using Drugs

Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation

doi: 10.1111/dom.14200 13

In many cases, the metabolic benefits of these medications may outweigh theoretical concerns, particularly for patients with significant obesity or poorly controlled diabetes, which themselves carry health risks

9598 Mechanistically, in the absence of impaired kidney function, more than 95% of TMAO in the human body is excreted through renal tubules or glomerular filtration, 99,100 suggesting a potential mechanism for elevated circulating TMAO levels when renal function is impaired

Iron British Dietetic Association