the most common reason was adverse reactions (n=48, 5.3%)
Here's how the two groups compared on reaching key weight loss milestones: Waist circumference also shrank more with tirzepatide: an average of 18.4 cm (about 7 inches) compared to 13.0 cm (about 5 inches) with semaglutide.[1] "The SURMOUNT-5 head-to-head results demonstrated tirzepatide led to greater weight reduction compared to semaglutide," said Dr
In the UK, there are specific NHS criteria: Semaglutide 2.4mg (Wegovy) : NICE technology appraisal TA875 recommends this only within specialist weight management services and for a maximum of 2 years on the NHS [2] Liraglutide 3.0mg (Saxenda) : NICE technology appraisal TA664 specifies that treatment should only continue beyond 12 weeks if you've lost at least 5% of your initial body weight Clinical trials have demonstrated that most people regain weight after stopping GLP-1 medications
The dose may be increased to 0.5 mg once a week for the next 4 weeks
Together, they raise downstream IGF-1, which is one of the actual drivers of muscle protein synthesis and tissue repair
Caramori G, Papi A: Oxidants and asthma
