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It is also involved in a series of physiological processes such as anti-tumor responses, control inflammation, and immune system homeostasis ( A team studied the immune responses of 54 COVID-19 patients and found that TNF- and IL-6 production by circulating monocytes was sustained

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In response to androgen stimulation, PCa cells recruit and activate CAFs, which significantly enhance the size of PC organoids by remodeling the ECM ( Cancer cells phenotypes and molecular functions are intrinsically tied to signals originating from outside the cell, particularly through interactions with ECM (Winkler et al., 2020)