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MT-1 can trigger mild nausea and appetite suppression in 1520% of subjects during initial dosing, typically resolving within 48 hours as melanocortin receptors downregulate

Triple therapy with glimepiride in patients with type 2 diabetes mellitus inadequately controlled by metformin and a thiazolidinedione: results of a 30-week, randomized, double-blind, placebo-controlled, parallel-group study

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But experts warn some side effects from the drugs could lead to dehydration, especially in extreme heat