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When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39's structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

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6 Conclusion Persistent barriers in solid tumor therapy, including uneven drug penetration, hypoxia- and acidosis-associated resistance and local immunosuppression, reflect structural and functional imbalances in the TME