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Even if the impact would be bigger than that, I think over a 10-year period, it will be manageable, and we will have adequate lead time to adjust and prepare for any changes that we see. On a more practical note, he said, Obesity rates around the world are very different, and we have one of the lowest exposures since 75% of our sales come from outside of the US and 40% of our sales are in emerging markets [where average BMIs are far lower]

This show-stopping move should only be performed if the patient requires additional weight loss or glycemic control and has tolerated the previous dosing steps without any missteps

According to the CDC, the US obesity prevalence was 41.9% in 2017 March 2020

DPP-4 inhibitors reduce HbA 1c levels and have a low risk of hypoglycaemia or other adverse events [38], except for a potential risk of hospitalisation for heart failure in the case of saxagliptin [38]

Do You Have to Take GLP-1s Forever

S12, Table S4)