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In summary, it is not difficult to find that continuous ER stress can accumulate necessary material conditions for the occurrence of ferroptosis such as ROS and Fe 2+ through UPR and can enhance the sensitivity of cells to ferroptosis by the increased expression of IRE1 in the process of JEV and HSV infections

Gttle P, Frster M, Weyers V, Kry P, Rejdak K, Hartung HP, Kremer D (2019) An unmet clinical need: roads to remyelination in MS