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Studies have demonstrated that 4% niacinamide can significantly reduce melasma severity ( Navarrete-Sols et al., Dermatology Research and Practice, 2011 ), improve moisture retention, and enhance overall texture ( Boo, 2021 )

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Crucially, resveratrol achieves these outcomes with a favorable safety profile, potentially circumventing the gastrointestinal intolerance associated with metformin, relapse risk after COCP discontinuation, and the teratogenicity concerns of anti-androgens

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Int Immunopharmacol 2005