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Glucagon-like peptide 1 (GLP-1): a potent gut hormone with a possible therapeutic perspective

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GLP-1 is a peptide secreted by L-type enteroendocrine cells in the ileum and colon in response to different nutrients, mainly glucose and lipids, whereas glucose-dependent insulinotropic polypeptide is produced by K cells present in the duodenum and the first portion of the jejunum

If you already deal with constipation on your GLP-1 , early dosing can make it worse for a few days

A good provider will take into account your goals, your sensitivity to medications, and your past experience with GI issues, then determine if microdosing is right for you