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Instead of a single disease, the authors introduce a spatiotemporal five-disease multimorbidity trajectory B1CB2GE (Brain1-Coronary-Brain2-Gastro-Enteric) and demonstrate that absorbed compounds from a traditional herbal formula (Bupleurum chinense Shugan-San

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Neurochemical Balance Restoration MSC-derived secretomes and extracellular vesicles enhance the GABAergic tone and inhibit excitatory glutamate signaling