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a , C57BL/6 J mice were infected via intravenous (i.v.) tail vein injections and intraperitoneally treated with 10 mg/kg rifampicin (Rif) (q.d.) or 100 mg/kg KL1 (b.i.d.) at 6 h post-infection (hpi) for 2 days

9 , e1003801 (2013)

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on the other, it remains vulnerable to -arrestin 2driven desensitization over time, which could limit its signaling durability in cells under chronic exposure