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[7] Population pharmacokinetic modeling reveals a biphasic disposition (distribution half-life 15-30 minutes

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Thymosin beta 4 is unusual in this compound class for having controlled human data, RGN-259 ophthalmic solution has been assessed in randomised, placebo-controlled, double-masked Phase 2 and Phase 3 trials in severe dry eye and neurotrophic keratopathy (Sosne et al., Cornea 2015 and Int J Mol Sci 2023)

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Small pieces of rectal tissue were also collected and stored in paraffin for later analysis