Competing Interests Blair Suter, Allison Bigeh, Timothy Frommeyer, and Laxmi Mehta declare that they have no conflicts of interest
doi: 10.1038/nm.4513 26 LanghorneJNdunguFMSponaasAMMarshK
Hypoxia and high-altitude adaptation promote the expression of genes related to oxygen homeostasis and antioxidant defense by upregulating HIFs
However, tirzepatide may cause higher rates of gastrointestinal side effects, particularly during the initial dose titration stage
In an editorial commenting on the TOGETHER-PsO trial, Michael Garshick, MD, of New York University School of Medicine, New York, NY, and Joel Gelfand, MD, of University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, wrote, patients with psoriasis are up to 2-fold more likely to have obesity and that obesity increases the risk of psoriasis and psoriatic arthritis, is directly associated with more extensive skin involvement, and reduces response to treatment and increases loss of response to treatment over time. Ixekizumab is an IL-17 inhibitor that has shown deep and durable skin clearance with a well-established safety profile, with superiority against other biologic agents in psoriasis
Weaning off tirzepatide requires the same patience and monitoring as the initial dose escalation phase
