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7) and induced ERK-CREB signaling activation, contributing to both Gcg and Vgf upregulation (Supplementary Fig

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A drug-sensitivity analysis showed that the cellular survival rate of VRK2-KO cells was significantly lower than that of VRK2-WT cells when treated with APR-017 or LCS3 (Fig

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Heres a breakdown of how they operate on fundamentally disparate biological circuits: This table makes the distinction crystal clear