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10.3390/ijms20071566 12 CorraoG.ZambonA.BagnardiV.D'AmicisA.KlatskyA.D'AmicisA.Collaborative SIDECIR Group (2001)

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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

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