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One study in patients with T2D demonstrated that intravenously administered GLP-1 significantly reduced fasting blood glucose (FBG) and, in a glucose-dependent manner, both enhanced insulin secretion and suppressed glucagon secretion ( Figure 19 - 2 )

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DPP-IV resistance is achieved through an -aminoisobutyric acid (Aib) substitution at position 2, blocking the proteolytic cleavage that normally inactivates incretin peptides within minutes of secretion

Gastrointestinal Hormones and Neurotransmitters

Lang A, Froelicher ES

Although not directly related to inflammation due to a physiologic change in the microenvironment, GLP-1RAs have the potential to replace current standard of care treatment for IIH and can ultimately contribute to improved patient outcomes in the field of neuro-ophthalmology