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B.1985Glutathione depletion greatly reduces neocarzinostatin cytotoxicity in Chinese hamster V79 cells.26083125 19

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This means that when mitochondrial activity is disrupted, as is the case with w inhibitors, low levels of GPX4 can still trigger ferroptosis

In the mitochondrial pathway, H 2 O 2 increases calcium ion concentrations within the mitochondria [77], regulates Bcl-2 family protein expression and activity, leading to decreased mitochondrial membrane potential, cytochrome c release, and ultimately triggering apoptosis [78]

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