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Endogenous glucagon-like peptide-1 reduces drinking behavior and is differentially engaged by water and food intakes in rats

Simultaneously, these medications suppress glucagon secretion from pancreatic alpha cells, further contributing to improved glycemic control

doi:10.3389/fphar.2023.1205207 Teixeira LCR, Luizon MR, Gomes KB

Extended-release exenatide (Bydureon BCise) has an apparent terminal half-life of approximately 2 weeks due to its depot formulation, with drug concentrations potentially persisting for 8-10 weeks after discontinuation

Key proposed mechanisms include: GLP-1 receptors on adipose-derived stem cells (ADSCs)

Have serious kidney or liver problems Have a severe gastrointestinal disease such as gastroparesis (delayed stomach emptying) Have diabetic ketoacidosis (a serious complication of diabetes)