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By improving metabolic regulation, moderating nutrient signaling, and reducing chronic inflammatory burden, these therapies may help alleviate physiological stress that contributes to age-related disease and functional decline

Both classes of agents reduce cardiometabolic risk factors such as HbA1c, body weight, blood pressure and albuminuria, although the effects of GLP-1 receptor agonists on glycemia and body weight are substantially greater than those of SGLT2 inhibitors

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