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[Abstract] FEBS Lett

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These included HSP40/70 co-chaperones (DNAJB and HSPA families), ER-stress and unfolded protein response mediators, and mitochondrial protein-folding and import regulators (CLPP, LONP1)

In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration