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Inflammation
FOXO4-DRI and Insulin Signaling In the context of longevity, FOXO4's activities are often linked through the insulin and insulin-like growth factor signaling (IIS) pathway
We refer readers to section XXIII.C
The immunohistochemical results showed that the expression of GLP-1R was down-regulated and the expression of STING, ACSL4 and TNF- was up-regulated in the RA group compared to the NC group
5.4 GLP-1s anti-apoptotic effects GLP-1 RAs exhibit strong anti-apoptotic effects by activating the PI3K/Akt pathway, which promotes cell survival by inhibiting pro-apoptotic factors such as Bax and caspase-3, while upregulating anti-apoptotic proteins like Bcl-2 (104106)
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