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According to the MHRA SmPC, Wegovy can cause a small mean increase in heart rate (approximately 24 beats per minute) with individual variability

Taken together, this could mean that TNF-stimulated cells are more adhesive in the beginning of their adhesion period, but the interaction with fibronectin additionally activates integrins independently of TNF, resulting in almost equal adhesion of +/TNF cells after 10 s

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doi: 10.1016/S0021-9258(18)67324-7 18 OrskovCHolstJJKnuhtsenSBaldisseraFGPoulsenSSNielsenOV

In this study, all MSPIs showed similar Lys/Arg ratios, indicating comparable effects on lipid metabolism