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The collagenase model replicates the matrix disorganization and degenerative pathology of clinical tendinopathy more closely than transection models, strengthening the relevance of the findings to the human chronic tendinopathy condition

Specifically, AHK-Cu might increase the expression of Bcl-2, an anti-apoptotic molecule, while reducing the levels of Bax, a pro-apoptotic counterpart

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model

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Furthermore, given that the outcomes of scaling and root planning (SRP) differ significantly between single-root and multiple-root teeth, we further categorized the treated teeth into a single-root group and a multiple-root group based on tooth position (Supplementary Table 16)

Some patients report noticing changes within 2-4 weeks, though individual responses vary