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Despite lacking MC-R binding motifs, KPV exhibits significant anti-inflammatory effects, making it a promising candidate for research into peptide compounds in immune-mediated inflammatory diseases like skin conditions, bowel diseases, asthma, and arthritis

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It also demonstrated the counteraction of the adverse effects of either NOS blockade (L-NAME) or NOS substrate L-arginine application (i.e., it opposed hypertension and pro-thrombotic effects (L-NAME) [26,55], as well as hypotension and anti-thrombotic (L-arginine) effects [26,55])

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10.1002/adfm.202405282 Adv