Other Safety Considerations Several additional safety topics are relevant to the clinical use of orforglipron: Gallbladder events: GLP-1 receptor agonists have been associated with increased rates of cholelithiasis and cholecystitis, likely mediated by rapid weight loss altering bile composition and gallbladder motility
Similar to previous studies, the adverse events included paresthesia, fatigue, and difficulty concentrating
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Contraindications and Cautions Pregnant or breastfeeding individuals should avoid BPC-157, as no data supports safety in these populations
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Tucker M, Keely A, Park JY, et al