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Although inhibition of PDH activity by overproducing pyruvate dehydrogenase kinase 4 in INS-1 cells did not affect GSIS [35], it is possible that PDH may play a supportive role for GSIS by providing acetyl-CoA to condense with the oxaloacetate produced by PC, to form citrate for downstream shuttles

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doi: 10.1080/09513590.2021.1878138 167 SukanBAkdevelioluYSukanVN