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Their uniqueness lies in achieving therapeutic goals by inhibiting NSP activation processes rather than directly antagonizing activated NSPs, establishing entirely new therapeutic avenues for neutrophil-mediated inflammatory respiratory disease management ( From drug development progress perspectives, brensocatib as the pioneering drug in this field has achieved remarkable results in clinical development

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11 , 10451054 (2018) V

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Common Side Effects Reported Across Phase 2 trials, participants experienced dose-dependent GI symptoms that are characteristic of GLP-1 receptor agonists: Nausea most frequent, especially during dose escalation Vomiting typically mild to moderate, subsiding with continued use Diarrhea and constipation fluctuating depending on individual tolerance Abdominal discomfort transient and often improved over time Dose-Response Relationship At lower doses (14 mg weekly), side effects were generally mild and manageable, though some participants still reported early GI symptoms

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