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A negative trend was observed for the frequency of the TYMS 6bp ins/del gene variant across Africa and Eurasia, but this was not significant ( r 2 =0.28, p =0.096)

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In both diabetic mice and high-glucose stimulated HK-2 cells, empagliflozin has been shown to enhance phosphorylation of AMPK at Thr172, which in turn promotes nuclear translocation of NRF2 (Lu et al., 2023)

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