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This mechanism is an attractive hypothesis to explain how metformin mediates a multitude of cellular effects via AMPK (100)

M., and van der Post, J

MARKET--MARCH 2000 Increases tissue insulin sensitivity decreased insulin resistance decreased insulinemia reduced fasting and postprandial hyperglycemia in Type II diabetics (non-insulin dependent diabetics, NIDDM) Rosiglitazone* (Avandia)-- FDA approved for management of Type II diabetes ---Concern about this agent responsible for excessive number of heart attack and congestive heart failure (2/2010) Approval as monotherapy or in combination with metformin (Glucophage) might be used with insulin or a sulfonylurea Apparently as effective does troglitazone (Rezulin) in controlling blood glucose without liver toxicity Long-term safety/benefits of rosiglitazone (Avandia) in patients with Type II diabetes: yet to be determined

As treatment options evolve, Read More GLP-1 Drugs and Beta-Cell Preservation: Can Early Treatment Slow Diabetes Progression

Although these medications share a common classification and some similarities, we will explore their distinctions concerning effectiveness, safety profiles, and potential side effects

PMID 41286875