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The primary outcome of interest was the incidence of dementia, Alzheimers disease, vascular dementia, frontotemporal dementia, Parkinsons disease, extrapyramidal and movement disorders, and dementia with Lewy bodies

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The study specifically focused on the liver's ability to produce urea-N (CUNS), which may serve as a measure of the liver's nitrogen processing capabilities

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The H 1 R protein is encoded by the HRH1 gene, the H 2 R protein is encoded by the HRH2 gene, the H 3 R protein is encoded by the HRH3 gene, and the H 4 R protein is encoded by the HRH4