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The missing values in this filtered data table were imputed with the R package missForest with default settings (70), using a random forest trained on the available data values to predict the missing data points

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Downregulated metabolites included glutamine, isoleucine, deamido-NAD + , and the upregulated metabolites included acylcarnitines, succinyladenosine, and leukotriene B4

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doi: 10.1089/ars.2020.8030